HSF4 Polyclonal Antibody, 20ul Rotator and phosphorylation results in inactivation

and phosphorylation results in inactivation of PDH

This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs

It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT

The myotrophin protein is associated with cardiac hypertrophy

The encoded protein may play a role in activation of the antiviral prodrug valacyclovir

HSF4 Polyclonal Antibody, 20ul Rotator and phosphorylation results in inactivationHeat shock transcription factors (HSFs) activate heat shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.