Trk B Polyclonal Antibody, 100ul[BT-AP09214] Cell Transfection channelopathy-associated insensitivity to pain

channelopathy-associated insensitivity to pain

The protein is localized to the nucleus

PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway

extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes

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Trk B Polyclonal Antibody, 100ul[BT-AP09214] Cell Transfection channelopathy-associated insensitivity to painNTRK2 encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in NTRK2 have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.