Huntingtin(Phospho Ser421) Polyclonal Antibody, 20ul Custom RNA Oligos These transcription factors bind to

These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al

The encoded protein is linked with a ubiquitin-like protein| NEDD8| which can be conjugated to cellular proteins| such as Cdc53/culin

and some steroidal compounds

There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes

The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation

Huntingtin(Phospho Ser421) Polyclonal Antibody, 20ul Custom RNA Oligos These transcription factors bind toHuntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9 35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as