Tenascin-C Polyclonal Antibody, 100ul[BT-AP08922] Cell Culture Flasks Mutations in this gene have

Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I

TNXB (tenascin XB) encodes a member of the tenascin family of extracellular matrix glycoproteins

Protein inhibitor of activated STAT 3 functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates

the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid

The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication

Tenascin-C Polyclonal Antibody, 100ul[BT-AP08922] Cell Culture Flasks Mutations in this gene haveTNC encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. Tenascin is homohexameric with disulfide linked subunits, and contains multiple EGF like and fibronectin type III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.