DNA-PKCS Polyclonal Antibody, 50ul[BT-AP02674] High Speed Micro-Centrifuges Defects in the erythropoietin receptor

Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis

Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy

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Alternate splicing of the gene results in several transcript variants encoding different isoforms

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DNA-PKCS Polyclonal Antibody, 50ul[BT-AP02674] High Speed Micro-Centrifuges Defects in the erythropoietin receptorPRKDC (protein kinase, DNA activated, catalytic polypeptide) encodes the catalytic subunit of the DNA dependent protein kinase (DNA PK). It functions with the Ku70 Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3 PI4 kinase family.