Mouse Dickkopf-related Protein 1, DKK1 ELISA Kit, 96T Human Genome Knockout Libraries Via the product sphingosine 1-phosphate

Via the product sphingosine 1-phosphate

It is sensitive to brefeldin A

Alternative splicing of this gene results in two transcript variants encoding distinct isoforms

Mutations in CYCS are associated with autosomal dominant nonsyndromic thrombocytopenia

tissue specificity:Detected in brain and spinal cord

Mouse Dickkopf-related Protein 1, DKK1 ELISA Kit, 96T Human Genome Knockout Libraries Via the product sphingosine 1-phosphateAntagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6 (PubMed: 18524778). Inhibits the pro apoptotic function of KREMEN1 in a Wnt independent manner, and has anti apoptotic activity (PubMed: 26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning