Rat Dipeptidase 2, DPEP2 ELISA Kit, 96T Human Genome Knockout Libraries Alternative splicing yields isoforms with

Alternative splicing yields isoforms with unique cytoplasmic tails

Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (PubMed: 20578263)

Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed: 29915298)

Isoform 2 is expressed in liver

SNCA (synuclein alpha) may serve to integrate presynaptic signaling and membrane trafficking

Rat Dipeptidase 2, DPEP2 ELISA Kit, 96T Human Genome Knockout Libraries Alternative splicing yields isoforms withDipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Does not hydrolyze cystinyl bis glycine. Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF kappa B inflammatory signaling pathway.