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This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation

T and B cells

Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection

along with ubiquitin-activating (E1) and ligating (E3) enzymes

U-PAR Rabbit Polyclonal Antibody, 20ul Antibodies Conquer any scientific challenge withActs as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis independent signal transduction activation effects of U PA. It is subject to negative feedback regulation by U PA which cleaves it into an inactive form. Contains 3 UPAR Ly6 domains. subunit: Monomer (Probable). Interacts with MRC2.