PERK Monoclonal Antibody, 100ul In vitro Assessment It serves a variety of

It serves a variety of functions

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily

Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase

Represses the transcription of a number of genes including gastrin and ornithine decarboxylase

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

PERK Monoclonal Antibody, 100ul In vitro Assessment It serves a variety ofThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in