Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephaly

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity

May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)

PTM:Phosphorylated on tyrosine residues in response to EGF and PDGF

Required for proper attachment of the midbody to the cell membrane during cytokinesis

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephalyCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical