IL-12B p40 Polyclonal Antibody, 50ul Subcellular Fractions Mutations in CASP10 are associated

Mutations in CASP10 are associated with type IIA autoimmune lymphoproliferative syndrome

This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined

The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids

Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity

Lumican may regulate collagen fibril organization and circumferential growth

IL-12B p40 Polyclonal Antibody, 50ul Subcellular Fractions Mutations in CASP10 are associatedThis gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to