ASPM Polyclonal Antibody, 100ul Site-directed Mutagenesis Inhibits expression of IL2RA on

Inhibits expression of IL2RA on activated T-cells and secretion of IL2

A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon

Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1)

Claudin 4 encoded by this intronless gene (CLDN4) belongs to the claudin family

Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity

ASPM Polyclonal Antibody, 100ul Site-directed Mutagenesis Inhibits expression of IL2RA onThis gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found