Paxillin Polyclonal Antibody, 100ul[BT-AP06956] Cell Labeling & Imaging Mutations in LMNA lead to

Mutations in LMNA lead to several diseases: emery-Dreifuss muscular dystrophy

ectrodactyly

which regulates cell proliferation

Alternatively spliced transcript variants have been observed for PBX4

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Paxillin Polyclonal Antibody, 100ul[BT-AP06956] Cell Labeling & Imaging Mutations in LMNA lead toPXN encodes a cytoskeletal protein involved in actin membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for PXN. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.