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AIRE-1 Polyclonal Antibody, 50ul[BT-AP00311] DNA Synthesis The protein encoded by this

SKU: 62385108741

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AIRE-1 Polyclonal Antibody, 50ul[BT-AP00311] DNA Synthesis The protein encoded by thisAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and

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Description

The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol| and is involved in the synthesis of Dol-P-Man| which is an essential glycosyl carrier lipid for C- and O-mannosylation| N- and O-linked glycosylation of proteins| and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum

which are involved in microtubule assembly and important for neurogenesis

It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle

neurotransmitter phenotype

EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins

AIRE-1 Polyclonal Antibody, 50ul[BT-AP00311] DNA Synthesis The protein encoded by thisAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The autoimmune regulator plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and

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