E2F-1(Phospho Thr433) Polyclonal Antibody, 100ul Isothermal Amplification HECT domain E3 ubiquitin ligases

HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates| thus targeting specific proteins for lysosomal degradation

E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates

Contains 6 HAT repeats

but is also expressed in liver

It encodes a cytosolic protein that is found at the highest level in erythrocytes

E2F-1(Phospho Thr433) Polyclonal Antibody, 100ul Isothermal Amplification HECT domain E3 ubiquitin ligasesThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which