SPTA1 Rabbit Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The gene was shown to

The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors

the ortholog of this gene is expressed in the cerebral cortex

many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals

Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death

In their unbound form

SPTA1 Rabbit Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The gene was shown toSpectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape arrangement of transmembrane proteins and organization of organelles. It is a tetramer made up of alpha beta dimers linked in a head to head arrangement. This gene is one member of a family of alpha spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats