DUX4 Rabbit Polyclonal Antibody, 100ul Diagnostic Probes & Oligos This gene is localized to

This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers

The encoded protein does not have a transmembrane domain

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor

a protein bearing immunoreceptor tyrosine-based activation motifs

while long expansions of this tract result in spinocerebellar ataxia-2

DUX4 Rabbit Polyclonal Antibody, 100ul Diagnostic Probes & Oligos This gene is localized toThis gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired like homeodomain