RFWD3 Polyclonal Antibody, 20ul Electronic Pipette GPR22 is a member of

GPR22 is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein

Suitable for fluorescence microscopy

and in a dimeric or multimeric form at the cell surface and in extracellular matrix

but causes G2-M arrest in p53-null or –mutant cells

The microsatellite is polymorphic

RFWD3 Polyclonal Antibody, 20ul Electronic Pipette GPR22 is a member ofRFWD3, also named as RNF201, is a E3 ubiquitin protein ligase that mediates the ubiquitination of p53 TP53 in the late response to DNA damage, and acts as a positive regulator of p53 TP53 stability, thereby regulating the G1 S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53 TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53 TP53