MDM2 Polyclonal Antibody, 20ul[BT-AP05303] DNA Fragments Take the risk and experience

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and plays an important role in transcriptional regulation

These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family

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Mutations in this gene are associated with type III Stickler syndrome

MDM2 Polyclonal Antibody, 20ul[BT-AP05303] DNA Fragments Take the risk and experienceMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many