NGN2 Polyclonal Antibody, 20ul Buffers & Solutions The SH2 (Src Homology 2)

The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell

associated with the phenotype named 'lurcher'

The protein (protein kinase

thereby activating the transcription factor

cytoskeletal reorganization

NGN2 Polyclonal Antibody, 20ul Buffers & Solutions The SH2 (Src Homology 2)This gene encodes a neural specific basic helix loop helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons.