PGFRL Polyclonal Antibody, 100ul Insect Expression NBPF1 is a member of

NBPF1 is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor

Rare transcript variants have been reported for this gene

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PGFRL Polyclonal Antibody, 100ul Insect Expression NBPF1 is a member ofThis gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non small cell lung cancers. This suggests this gene product may function as a tumor suppressor.