p53 Polyclonal Antibody, 100ul[BT-AP06814] Recombinant Protein Expression |subcellular location:Unphosphorylated form localizes in

|subcellular location:Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation

Binds to the proximal sequence element (PSE)

2002 [PubMed 11836249])

and mutations in it have been associated with malignant rhabdoid tumors

The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins

p53 Polyclonal Antibody, 100ul[BT-AP06814] Recombinant Protein Expression |subcellular location:Unphosphorylated form localizes inTP53 (tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni