Crystallin-alphaC Polyclonal Antibody, 20ul In vitro Assessment Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding multiple isoforms have been observed for ARHGAP12

Methyltransferase

which regulates the extent of phosphorylation of MLC

The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration

The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate

Crystallin-alphaC Polyclonal Antibody, 20ul In vitro Assessment Alternatively spliced transcript variants encodingThe protein encoded by this gene belongs to the superfamily of small heat shock proteins containing a conservative alpha crystallin domain at the C terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell