USP19 Polyclonal Antibody, 100ul Proteases Mutations in this gene cause

Mutations in this gene cause spinocerebellar ataxia type 15| a disease associated with an heterogeneous group of cerebellar disorders

but the encoded protein only shows sequence identity with the upstream gene product

placental protein 14

which is involved in intracellular trafficking and chromosome segregation during mitosis

developmental stage:Expressed throughout the cell cycle

USP19 Polyclonal Antibody, 100ul Proteases Mutations in this gene causeDeubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic reticulum associated degradation