RN123 Polyclonal Antibody, 50ul Antibody Development Mutations in NODAL are associated

Mutations in NODAL are associated with heterotaxy

This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids

called PPARs

May regulate osteoblast proliferation and differentiation

It also plays a role in the WNT and PI3K signaling pathways

RN123 Polyclonal Antibody, 50ul Antibody Development Mutations in NODAL are associatedThe protein encoded by this gene contains a C terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein protein and protein DNA interactions, and an N terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.