IGF-IR Polyclonal Antibody, 100ul[BT-AP04398] Polyclonal Antibody Preparation Knockout studies in mice suggest

Knockout studies in mice suggest that the different receptors

subcellular location:Localized to plasma membrane coated pits

it is not known whether this trimer is composed of one or more than one alpha chain isomer

Alternate transcriptional splice variants

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IGF-IR Polyclonal Antibody, 100ul[BT-AP04398] Polyclonal Antibody Preparation Knockout studies in mice suggestIGF1R, this receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms