AAK1 Polyclonal Antibody, 50ul Antibody Humanization The encoded protein is a

The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin

This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm

This gene encodes a member of the type 1 cytokine receptor family

type I receptors phosphorylate cytoplasmic SMAD transcription factors

which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains

AAK1 Polyclonal Antibody, 50ul Antibody Humanization The encoded protein is aAdaptor related protein complex 2 (AP 2 complexes) functions during receptor mediated endocytosis to trigger clathrin assembly, interact with membrane bound receptors, and recruit encodytic accessory factors. AAK1 encodes a member (AP2 associated kinase 1) of the SNF1 subfamily of Ser Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP 2 complex, which promotes binding of AP 2 to sorting signals found in membrane