Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 100ul Glassware Sets Mutations in THRB are known

Mutations in THRB are known to be a cause of generalized thyroid hormone resistance (GTHR)

The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor

have been shown to be involved in protein-protein interaction

heterodimerize with the related platelet-derived growth factor subunit B

Members of the F-box protein family

Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 100ul Glassware Sets Mutations in THRB are knownThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy independent docking of the protein to the nuclear envelope and the second is an energy dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in