Rat Urocortin, UCN LISA KIT, 96T Site-directed Mutagenesis The encoded protein promotes angiogenesis

The encoded protein promotes angiogenesis and endothelial cell growth

Multiple alternative transcript variants have been described for this gene

In addition| this protein interacts with and phosphorylates BRCA1| allowing BRCA1 to restore survival after DNA damage

11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia

it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer

Rat Urocortin, UCN LISA KIT, 96T Site-directed Mutagenesis The encoded protein promotes angiogenesisActs in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed: 7477349). Binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed: 21540451).