ENOB Polyclonal Antibody, 100ul Palm Micro Centrifuges VAV1 (vav guanine nucleotide exchange

VAV1 (vav guanine nucleotide exchange factor 1) is a member of the VAV gene family

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7)

Contains 1 ARM repeat

The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export

Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis

ENOB Polyclonal Antibody, 100ul Palm Micro Centrifuges VAV1 (vav guanine nucleotide exchangeThis gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.