Ezrin(Phospho Tyr353) Polyclonal Antibody, 20ul Sample Library Tubes Mutations in this gene are

Mutations in this gene are a cause of colorectal cancer (CRC)

The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells

It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction

such as RAPGEF5 (Rap guanine nucleotide exchange factor 5)

This family also includes genes in several genomes| including human| that appear to have been derived from the piggyBac transposons

Ezrin(Phospho Tyr353) Polyclonal Antibody, 20ul Sample Library Tubes Mutations in this gene areThe cytoplasmic peripheral membrane protein encoded by this gene functions as a protein tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been