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Tuberin/TSC2(Phospho-Ser664) Rabbit Polyclonal Antibody, 50ul Long RNA Synthesis GAS1 blocks entry to S

SKU: 32822065690

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Tuberin/TSC2(Phospho-Ser664) Rabbit Polyclonal Antibody, 50ul Long RNA Synthesis GAS1 blocks entry to SMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Description

GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells

The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK

Following type I IFN binding to cell surface receptors| Jak kinases (TYK2 and JAK1) are activated| leading to tyrosine phosphorylation of STAT1 and STAT2

Three transcript variants encoding two different proteins have been found for CSNK2A1

Tuberin/TSC2(Phospho-Ser664) Rabbit Polyclonal Antibody, 50ul Long RNA Synthesis GAS1 blocks entry to SMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

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