TRIB3 Polyclonal Antibody, 20ul Filtration Eukaryotic translation initiation factor 4E

Eukaryotic translation initiation factor 4E encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex

is well conserved

A similar duplicated gene is located next to this gene on chromosome 16

This protein was shown to activate IkappaB kinases

Inhibits the transcriptional activation mediated by PAX5

TRIB3 Polyclonal Antibody, 20ul Filtration Eukaryotic translation initiation factor 4EThe protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF kappaB. The encoded protein is a negative regulator of NF kappaB and can also sensitize cells to TNF and TRAIL induced apoptosis. In addition, this protein can negatively regulate the cell survival serine threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants.