PUMA Polyclonal Antibody, 50ul Centrifuges and thus functions as a

and thus functions as a regulator of cytokine receptor signaling

Over-expression of this gene has been found in patients with polycythemia rubra vera

This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18

which suggests a role in the JNK signaling pathway

This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150)

PUMA Polyclonal Antibody, 50ul Centrifuges and thus functions as aBBC3 encodes a member of the BCL 2 family of proteins. This family member belongs to the BH3 only pro apoptotic subclass. BCL2 binding component 3 cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti apoptotic Bcl 2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro apoptotic role, BBC3 is a potential drug target for cancer