AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis The encoded protein may function

The encoded protein may function as a transcription factor

Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene

functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass

but the exact function of the encoded protein is unknown

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AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis The encoded protein may functionAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein (autoimmune regulator) plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with