Chk1(Phospho Ser301) Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Defects in this gene are

Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer

also known as Mitochondrial 2-oxoglutarate/malate carrier protein

The encoded protein forms homodimers with the retinoic acid

Within leukocyte population more abundant expression in neutrophils and eosinophils

The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding

Chk1(Phospho Ser301) Polyclonal Antibody, 50ul Monoclonal Antibody Preparation Defects in this gene areThe protein encoded by this gene belongs to the Ser Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells