Mob1A Polyclonal Antibody, 50ul[BT-AP11421] Pipette Controller The protein encoded by ARHGEF5

The protein encoded by ARHGEF5 (Rho guanine nucleotide exchange factor 5) may form a complex with G proteins and stimulate Rho-dependent signals

|PTM:Constitutively sumoylated by SUMO1| SUMO2 and SUMO3

GO annotations related to this gene include calcium ion binding and protein heterodimerization activity

Activating transcription factor 2 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions

Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids

Mob1A Polyclonal Antibody, 50ul[BT-AP11421] Pipette Controller The protein encoded by ARHGEF5The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.