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Rb Polyclonal Antibody, 100ul[BT-AP07686] Vessels COL4A3 is organized in a

SKU: 24381194506

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Rb Polyclonal Antibody, 100ul[BT-AP07686] Vessels COL4A3 is organized in aThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

COL4A3 is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter

Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin

which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif)

Serum level of this protein

Rb Polyclonal Antibody, 100ul[BT-AP07686] Vessels COL4A3 is organized in aThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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