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Akt1 Polyclonal Antibody, 100ul[BT-AP00348] Contamination Detection & Removal The encoded protein may function

SKU: 22237091599

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Akt1 Polyclonal Antibody, 100ul[BT-AP00348] Contamination Detection & Removal The encoded protein may functionThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a

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Description

The encoded protein may function by altering local chromatin structure

The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types

this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH)

Activity of this receptor has also been linked to carcinogenesis

and has been implicated in the pathogenesis of various malignancies and diseases of the immune system

Akt1 Polyclonal Antibody, 100ul[BT-AP00348] Contamination Detection & Removal The encoded protein may functionThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a

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