Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The encoded protein plays a

The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails

and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons

in addition to the MAPKK pathways

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1

targeting the integrin for internalization and degradation

Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The encoded protein plays aMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.