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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependent

SKU: 21244138705

4.1
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p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependentThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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Description

Calcium-dependent

Seems to prevent the degeneration of motor axons after axotomy

In addition| protein levels decrease in the presence of natural killer lytic-associated molecule| suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein

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The protein encoded by CDKL3 (cyclin dependent kinase like 3) is a member of cyclin-dependent protein kinase (CDK) family

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets Calcium-dependentThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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