TM165 Rabbit Polyclonal Antibody, 50ul Cell Culture The encoded protein tranduces signals

The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex

but the full-length nature of some variants has not been defined

chondriotin sulfate

receptor-mediated endocytosis

Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546

TM165 Rabbit Polyclonal Antibody, 50ul Cell Culture The encoded protein tranduces signalsThis gene encodes a predicted transmembrane protein with a perinuclear Golgi like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants.