p27 Polyclonal Antibody, 50ul[BT-AP06753] Centrifuge Tube (Bottle) The protease is packaged into

The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain

which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus

It may be a component of a prelamin A endoprotease complex

using S-adenosylmethionine (AdoMet) as the methyl donor

Sequence analysis identified three transcript variants

p27 Polyclonal Antibody, 50ul[BT-AP06753] Centrifuge Tube (Bottle) The protease is packaged intoCDKN1B encodes a cyclin dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A p21. The cyclin dependent kinase inhibitor 1B binds to and prevents the activation of cyclin E CDK2 or cyclin D CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the