NKX22 Polyclonal Antibody, 50ul Stepper The protein encoded by PMS2

The protein encoded by PMS2 (PMS1 homolog 2

Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap

Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found

It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel

implying different ligand specificity

NKX22 Polyclonal Antibody, 50ul Stepper The protein encoded by PMS2The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2 4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2 8. The encoded protein is likely to be a nuclear transcription factor.