SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 20ul Enzymes & Activity Assays The encoded protein is the

The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage

This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs

a central coiled-coil region and a highly conserved carboxyl terminal domain

An important paralog of this gene is R3HCC1

process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction

SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 20ul Enzymes & Activity Assays The encoded protein is theThis gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular