Arkadia Polyclonal Antibody, 100ul Hepatocytes It participates in apoptosis signaling

It participates in apoptosis signaling through highly specific protein-protein homophilic interactions

The core complex associates with MTA2| MBD2| MBD3| MTA1L1| CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex| or with SIN3| SAP18 and SAP30 to form the SIN3 HDAC complex

This heterodimer binds E-box enhancer elements upstream of Period (PER1

Overexpression of PBK has been implicated in tumorigenesis

The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions

Arkadia Polyclonal Antibody, 100ul Hepatocytes It participates in apoptosis signalingThe protein encoded by RNF111 (ring finger protein 111) is a nuclear RING domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) beta NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF beta target gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the