PKR(Phospho Thr258) Polyclonal Antibody, 50ul Cell fragmentation and collection leading to activate transcription of

leading to activate transcription of the beta-globin locus (By similarity)

Acting as a GTPase activating protein (GAP)

As such| it may play a role in anti-viral immunity

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily

IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al

PKR(Phospho Thr258) Polyclonal Antibody, 50ul Cell fragmentation and collection leading to activate transcription ofThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.