Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing suppressed by proinflammatory mediators like

suppressed by proinflammatory mediators like lipopolysaccharide (LPS)| Interferon gamma/IFNG| and tumor necrosis factor alpha

This gene is a member of the metallocarboxypeptidase gene family

Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism

This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus

Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing suppressed by proinflammatory mediators likeThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding