USP16 Polyclonal Antibody, 100ul Serological Pipets Mutations in this gene may

Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients

and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression

and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A

the DHJHC m-protein or the p55 chain

INHBC encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins

USP16 Polyclonal Antibody, 100ul Serological Pipets Mutations in this gene mayUSP16 encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.