PEK/PERK Polyclonal Antibody, 100ul Organelle Studies This protein has been shown
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PEK/PERK Polyclonal Antibody, 100ul Organelle Studies This protein has been shownThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in
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